Mast cell regulation of airway smooth muscle function in asthma

Mast cell regulation of airway smooth muscle function in asthma.

A sthma is a common disease affecting f10% of the adult Western population [1, 2]. It is characterised by the presence of variable and potentially reversible airflow obstruction, which occurs as the result of bronchoconstriction, airway mucus plugging and airway oedema. Pathologically there is evidence of airway inflammation and remodelling [3– 7]. The mucosal inflammatory infiltrate commonly c...

Mast Cell-Airway Smooth Muscle Crosstalk

T-helper cell type 2 (Th2) polarization of the infl ammatory response is an important component of the asthma paradigm. 5,6 A major effector axis resulting in this polarization is the recognition of allergen presented by dendritic cells in local lymph nodes to the CD4 1 T cell. The differentiation of naive T cells or reactivation of memory T cells is dependent upon costimulatory molecules, such...

Mast Cell Tryptase Causes Airway Smooth Muscle

Supernatants obtained by degranulation of dog mastocytoma cells greatly increased the sensitivity and the magnitude of the contractile response of isolated dog bronchial smooth muscle to histamine. The enhanced contractile response was reversed completely by Hi-receptor antagonists and was prevented by an inhibitor of tryptase (a major protease released with histamine from secretory granules of...

Human mast cell and airway smooth muscle cell interactions: implications for asthma.

Asthma is characterized by inflammation, hyperresponsiveness, and remodeling of the airway. Human mast cells (HMCs) play a central role in all of these changes by releasing mediators that cause exaggerated bronchoconstriction, induce human airway smooth muscle (HASM) cell proliferation, and recruit and activate inflammatory cells. Moreover, the number of HMCs present on asthmatic HASM is increa...

Recruitment in Asthma Muscle Cells Contributes to Mast Cell Fraktalkine Produced by Airway Smooth